8DEG
Crystal structure of DLK in complex with inhibitor DN0011197
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase kinase kinase 12 | polymer | 322 | 36409.8 | 1 | UniProt (Q12852) Pfam (PF07714) In PDB | Homo sapiens (human) | Dual leucine zipper bearing kinase,DLK,Leucine-zipper protein kinase,ZPK,MAPK-upstream kinase,MUK,Mixed lineage kinase |
2 | A | methyl (1S,4S)-5-{(4P)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1R,4R)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | non-polymer | 473.5 | 1 | Chemie (SIQ) | |||
3 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 115 - 402 (UniProt: Q12852)
PDB | External Database | Details |
---|---|---|
Ile 90 | - | expression tag |
Phe 91 | - | expression tag |
Arg 92 | - | expression tag |
Ile 93 | - | expression tag |
Ile 94 | - | expression tag |
His 95 | - | expression tag |
Thr 96 | - | expression tag |
Val 97 | - | expression tag |
Pro 98 | - | expression tag |
Pro 99 | - | expression tag |
Ser 100 | - | expression tag |
Gly 101 | - | expression tag |
Ala 102 | - | expression tag |
Asp 103 | - | expression tag |
Pro 104 | - | expression tag |
Gly 105 | - | expression tag |
Pro 106 | - | expression tag |
Lys 107 | - | expression tag |
Arg 108 | - | expression tag |
Ala 109 | - | expression tag |
Glu 110 | - | expression tag |
Phe 111 | - | expression tag |
Met 112 | - | expression tag |
Gly 113 | - | expression tag |
Ser 114 | - | expression tag |
Gly 403 | - | expression tag |
Asn 404 | - | expression tag |
Ser 405 | - | expression tag |
His 406 | - | expression tag |
His 407 | - | expression tag |
His 408 | - | expression tag |
His 409 | - | expression tag |
His 410 | - | expression tag |
His 411 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36409.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 473.5 | |
All* | Total formula weight | 36883.3 |