8D52

Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing (2-naphthyl)-beta-3-homoalanine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Parathyroid hormone/parathyroid hormone-related peptide receptor	polymer	103	11995.7	1	UniProt (Q03431) Pfam (PF02793) In PDB	Homo sapiens (human)	PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor
2	B	PTHrP[1-36]	polymer	22	2833.3	1	UniProt (P12272) In PDB	Homo sapiens
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5		water	water		18.0	44	Chemie (HOH)

Sequence modifications

A: 29 - 174 (UniProt: Q03431)

PDB	External Database	Details
Gly 28	-	expression tag
-	Ser 61	deletion
-	Ile 62	deletion
-	Met 63	deletion
-	Glu 64	deletion
-	Ser 65	deletion
-	Asp 66	deletion
-	Lys 67	deletion
-	Gly 68	deletion
-	Trp 69	deletion
-	Thr 70	deletion
-	Ser 71	deletion
-	Ala 72	deletion
-	Ser 73	deletion
-	Thr 74	deletion
-	Ser 75	deletion
-	Gly 76	deletion
-	Lys 77	deletion
-	Pro 78	deletion
-	Arg 79	deletion
-	Lys 80	deletion
-	Asp 81	deletion
-	Lys 82	deletion
-	Ala 83	deletion
-	Ser 84	deletion
-	Gly 85	deletion
-	Lys 86	deletion
-	Leu 87	deletion
-	Tyr 88	deletion
-	Pro 89	deletion
-	Glu 90	deletion
-	Ser 91	deletion
-	Glu 92	deletion
-	Glu 93	deletion
-	Asp 94	deletion
-	Lys 95	deletion
-	Glu 96	deletion
-	Ala 97	deletion
-	Pro 98	deletion
-	Thr 99	deletion
-	Gly 100	deletion
-	Ser 101	deletion
-	Arg 102	deletion
-	Tyr 103	deletion
-	Arg 104	deletion

B: 15 - 36 (UniProt: P12272)

PDB	External Database	Details
Qf0 31	Ile 67	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	14829.0
Non-Polymers*	Number of molecules	2
	Total formula weight	127.5
All*	Total formula weight	14956.4

*Water molecules are not included.