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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8CAH

Cryo-EM structure of native Otu2-bound ubiquitinated 43S pre-initiation complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1lEukaryotic translation initiation factor 3 subunit Ipolymer34738803.41UniProt (A0A6A5PTA5)
Pfam (PF00400)
UniProt (by SIFTS) (P40217)
In PDB		Saccharomyces cerevisiae W303
2rEukaryotic translation initiation factor 3 subunit Gpolymer27430547.51UniProt (A0A8H8UNW9)
Pfam (PF12353)
Pfam (PF00076)
UniProt (by SIFTS) (Q04067)
In PDB		Saccharomyces cerevisiae W303
3oEukaryotic translation initiation factor 3 subunit Apolymer964110517.61UniProt (P38249)
In PDB		Saccharomyces cerevisiae W303eIF3a,Eukaryotic translation initiation factor 3 110 kDa subunit homolog,eIF3 p110,Translation initiation factor eIF3,p110 subunit homolog
4pEukaryotic translation initiation factor 3 subunit Bpolymer76388241.81UniProt (A0A8H4F8W9)
Pfam (PF00076)
Pfam (PF08662)
UniProt (by SIFTS) (P06103)
In PDB		Saccharomyces cerevisiae W303
5qEukaryotic translation initiation factor 3 subunit Cpolymer81293310.21UniProt (A0A8H4BZ29)
Pfam (PF05470)
Pfam (PF01399)
UniProt (by SIFTS) (P32497)
In PDB		Saccharomyces cerevisiae W303
6iEukaryotic translation initiation factor 4Cpolymer15317462.21UniProt (A0A6A5PU90)
Pfam (PF01176)
UniProt (by SIFTS) (P38912)
In PDB		Saccharomyces cerevisiae W303
7mSUI1 isoform 1polymer10812330.11UniProt (A0A6A5Q4K5)
Pfam (PF01253)
UniProt (by SIFTS) (P32911)
In PDB		Saccharomyces cerevisiae W303
8jRNA recognition motif (unknown)polymer776571.11Saccharomyces cerevisiae W303
9218S ribosomal RNApolymer1800579761.91Saccharomyces cerevisiae W303
10P40S ribosomal protein S0-Apolymer25228051.31UniProt (P32905)
Pfam (PF00318)
In PDB		Saccharomyces cerevisiae W303Nucleic acid-binding protein NAB1A,Small ribosomal subunit protein uS2-A
11Q40S ribosomal protein S1-Apolymer25528798.51UniProt (P33442)
Pfam (PF01015)
In PDB		Saccharomyces cerevisiae W303RP10A,Small ribosomal subunit protein eS1-A
12R40S ribosomal protein S2polymer25427490.81UniProt (P25443)
Pfam (PF00333)
Pfam (PF03719)
In PDB		Saccharomyces cerevisiae W303Omnipotent suppressor protein SUP44,RP12,S4,Small ribosomal subunit protein uS5,YS5
13S40S ribosomal protein S4-Bpolymer26129469.31UniProt (P0CX36)
Pfam (PF08071)
Pfam (PF01479)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)
In PDB		Saccharomyces cerevisiae W303RP5,S7,Small ribosomal subunit protein eS4-B,YS6
14T40S ribosomal protein S6-Bpolymer23627054.51UniProt (P0CX38)
Pfam (PF01092)
In PDB		Saccharomyces cerevisiae W303RP9,S10,Small ribosomal subunit protein eS6-B,YS4
15V40S ribosomal protein S8-Apolymer20022537.81UniProt (P0CX39)
Pfam (PF01201)
In PDB		Saccharomyces cerevisiae W303
16W40S ribosomal protein S9-Apolymer19722487.91UniProt (O13516)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Saccharomyces cerevisiae W303
17X40S ribosomal protein S11-Apolymer15617785.91UniProt (P0CX47)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Saccharomyces cerevisiae W303
18Y40S ribosomal protein S13polymer15117059.91UniProt (P05756)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Saccharomyces cerevisiae W303S27a,Small ribosomal subunit protein uS15,YS15
19Z40S ribosomal protein S14-Apolymer13714562.71UniProt (P06367)
Pfam (PF00411)
In PDB		Saccharomyces cerevisiae W303
20a40S ribosomal protein S21-Apolymer879758.81UniProt (P0C0V8)
Pfam (PF01249)
In PDB		Saccharomyces cerevisiae W303S26,Small ribosomal subunit protein eS21-A,YS25
21b40S ribosomal protein S22-Apolymer13014650.11UniProt (P0C0W1)
Pfam (PF00410)
In PDB		Saccharomyces cerevisiae W303
22c40S ribosomal protein S23-Apolymer14516073.91UniProt (P0CX29)
Pfam (PF00164)
In PDB		Saccharomyces cerevisiae W303RP37,S28,Small ribosomal subunit protein uS12-A,YS14
23d40S ribosomal protein S24-Apolymer13515362.81UniProt (P0CX31)
Pfam (PF01282)
In PDB		Saccharomyces cerevisiae W303RP50,Small ribosomal subunit protein eS24-A
24e40S ribosomal protein S26-Apolymer11913538.91UniProt (P39938)
Pfam (PF01283)
In PDB		Saccharomyces cerevisiae W303Small ribosomal subunit protein eS26-A
25f40S ribosomal protein S27-Apolymer828893.41UniProt (P35997)
Pfam (PF01667)
In PDB		Saccharomyces cerevisiae W303RP61,Small ribosomal subunit protein eS27-A,YS20
26g40S ribosomal protein S30-Apolymer637137.51UniProt (P0CX33)
Pfam (PF04758)
In PDB		Saccharomyces cerevisiae W303Small ribosomal subunit protein eS30-A
27ERPS15 isoform 1polymer14216031.91UniProt (Q01855)
Pfam (PF00203)
In PDB		Saccharomyces cerevisiae W303
28A40S ribosomal protein S3polymer24026542.81UniProt (P05750)
Pfam (PF07650)
Pfam (PF00189)
In PDB		Saccharomyces cerevisiae W303RP13,Small ribosomal subunit protein uS3,YS3
29B40S ribosomal protein S5polymer22525072.61UniProt (P26783)
Pfam (PF00177)
In PDB		Saccharomyces cerevisiae W303RP14,S2,Small ribosomal subunit protein uS7,YS8
30C40S ribosomal protein S10-Apolymer10512757.41UniProt (Q08745)
Pfam (PF03501)
In PDB		Saccharomyces cerevisiae W303Small ribosomal subunit protein eS10-A
31D40S ribosomal protein S12polymer14315488.61UniProt (P48589)
Pfam (PF01248)
In PDB		Saccharomyces cerevisiae W303Small ribosomal subunit protein eS12
32F40S ribosomal protein S16-Apolymer14315877.51UniProt (P0CX51)
Pfam (PF00380)
In PDB		Saccharomyces cerevisiae W303RP61R,Small ribosomal subunit protein uS9-A
33H40S ribosomal protein S17-Apolymer13615820.41UniProt (P02407)
Pfam (PF00833)
In PDB		Saccharomyces cerevisiae W303RP51A,Small ribosomal subunit protein eS17-A
34I40S ribosomal protein S18-Apolymer14617071.61UniProt (P0CX55)
Pfam (PF00416)
In PDB		Saccharomyces cerevisiae W303Small ribosomal subunit protein uS13-A
35J40S ribosomal protein S19-Apolymer14415942.11UniProt (P07280)
Pfam (PF01090)
In PDB		Saccharomyces cerevisiae W303RP55A,S16a,Small ribosomal subunit protein eS19-A,YP45,YS16A
36K40S ribosomal protein S20polymer12113929.01UniProt (P38701)
Pfam (PF00338)
In PDB		Saccharomyces cerevisiae W303Small ribosomal subunit protein uS10
37L40S ribosomal protein S25-Apolymer10812067.31UniProt (Q3E792)
Pfam (PF03297)
In PDB		Saccharomyces cerevisiae W303RP45,S31,Small ribosomal subunit protein eS25-A,YS23
38MRPS29A isoform 1polymer566675.71UniProt (P41057)
Pfam (PF00253)
In PDB		Saccharomyces cerevisiae W303
39N40S ribosomal protein S31polymer768703.51UniProt (P05759)
Pfam (PF01599)
In PDB		Saccharomyces cerevisiae W303CEP76,S37,Small ribosomal subunit protein eS31,YS24
40OGuanine nucleotide-binding protein subunit beta-like proteinpolymer31934841.21UniProt (P38011)
Pfam (PF00400)
In PDB		Saccharomyces cerevisiae W303Receptor for activated C kinase,Receptor of activated protein kinase C 1,RACK1,Small ribosomal subunit protein RACK1
41h40S ribosomal protein S28-Apolymer677605.81UniProt (Q3E7X9)
Pfam (PF01200)
In PDB		Saccharomyces cerevisiae W303S33,Small ribosomal subunit protein eS28-A,YS27
42z, yEukaryotic translation initiation factor 3 subunit Jpolymer26529611.22UniProt (A0A6A5PQW9)
Pfam (PF08597)
UniProt (by SIFTS) (Q05775)
In PDB		Saccharomyces cerevisiae W303
43xRLI1 isoform 1polymer60868433.21UniProt (A0A6A5Q259)
Pfam (PF04068)
Pfam (PF00037)
Pfam (PF00005)
UniProt (by SIFTS) (Q03195)
In PDB		Saccharomyces cerevisiae W303
44k60S ribosomal protein L40-Apolymer768576.81UniProt (P0CH08)
Pfam (PF00240)
In PDB		Saccharomyces cerevisiae W303CEP52,Large ribosomal subunit protein eL40-A
45n60S ribosomal protein L41-Apolymer253354.21UniProt (P0CX86)
Pfam (PF05162)
In PDB		Saccharomyces cerevisiae W303L47,Large ribosomal subunit protein eL41-A,YL41
46GOTU domain-containing protein 2polymer30736157.01UniProt (P38747)
Pfam (PF02338)
In PDB		Saccharomyces cerevisiae W303
47U40S ribosomal protein S7-Apolymer19021658.21UniProt (P26786)
Pfam (PF01251)
In PDB		Saccharomyces cerevisiae W303RP30,RP40,Small ribosomal subunit protein eS7-A
482, x, S, BMAGNESIUM IONnon-polymer24.380Chemie (MG)
49M, NZINC IONnon-polymer65.42Chemie (ZN)
50xIRON/SULFUR CLUSTERnon-polymer351.62Chemie (SF4)
51xADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
Sequence modifications
k: 1 - 76 (UniProt: P0CH08)
PDBExternal DatabaseDetails
Pro 19Ser 19conflict
Glu 24Asp 24conflict
Ala 28Ser 28conflict
G: 1 - 307 (UniProt: P38747)
PDBExternal DatabaseDetails
Ser 178Cys 178conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains48
Total formula weight1740089.6
Non-Polymers*Number of molecules85
Total formula weight3205.7
All*Total formula weight1743295.3
*Water molecules are not included.

220113

PDB entries from 2024-05-22

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