8C8T

cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F, G	Envelope glycoprotein gp160	polymer	469	52551.5	3	UniProt (Q2N0S5) Pfam (PF00516) In PDB	Human immunodeficiency virus 1	Env polyprotein
2	B, I, J	Gp41 Bg505 T332n Sosip.664	polymer	145	16431.6	3		Human immunodeficiency virus 1
3	C, H	IgG EPTC112 Fab fragment heavy chain	polymer	233	25320.4	2		Homo sapiens (Human)
4	R, S	IgG 3BNC117 Fab heavy chain	polymer	226	24640.5	2		Homo sapiens (Human)
5	T, U	IgG 3BNC117 Fab Light Chain	polymer	206	23022.7	2		Homo sapiens (Human)
6	D, K	IgG EPTC112 Fab Light Chain	polymer	216	22680.9	2		Homo sapiens (Human)
7	a, b, E, M, N...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	11	In PDB GlyTouCan (G42666HT)
8	L, X	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
9	V	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
10	A, F, G, T	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	24	Chemie (NAG)

Sequence modifications

A, F, G: 34 - 504 (UniProt: Q2N0S5)

PDB	External Database	Details
Asn 332	Thr 330	conflict
Cys 501	Ala 498	conflict

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	398278.3
Branched	Number of molecules	14
	Total formula weight	6590.2
Non-Polymers*	Number of molecules	24
	Total formula weight	5309.0
All*	Total formula weight	410177.5

*Water molecules are not included.