8BTQ
Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) In PDB | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B | Carbohydrate-responsive element-binding protein | polymer | 19 | 2482.9 | 1 | UniProt (Q9NP71) In PDB | Homo sapiens | ChREBP,Class D basic helix-loop-helix protein 14,bHLHd14,MLX interactor,MLX-interacting protein-like,WS basic-helix-loop-helix leucine zipper protein,WS-bHLH,Williams-Beuren syndrome chromosomal region 14 protein |
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | A | [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid | non-polymer | 335.3 | 1 | Chemie (OQE) | |||
| 5 | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29025.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 408.2 | |
| All* | Total formula weight | 29434.0 |
