8B2J
Crystal structure of human STING in complex with ADU-S100
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Stimulator of interferon genes protein | polymer | 242 | 27180.6 | 2 | UniProt (Q86WV6) Pfam (PF15009) In PDB | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | A | (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol | non-polymer | 690.5 | 1 | Chemie (GJF) | |||
| 3 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | A, B | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
| 5 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A, B: 138 - 379 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Arg 232 | His 232 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54361.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 954.6 | |
| All* | Total formula weight | 55315.9 |
