8AYH

Structure of Complement C5 in Complex with small molecule inhibitor and CVF

Replaces:  6I2X

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	Complement C5 beta chain	polymer	657	73615.8	1	UniProt (P01031) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) In PDB	Homo sapiens (human)
2	A	Complement C5 alpha chain	polymer	999	112635.0	1	UniProt (P01031) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) Pfam (PF07677) Pfam (PF01759) In PDB	Homo sapiens (human)
3	B	Cobra venom factor	polymer	1642	184726.7	1	UniProt (Q91132) Pfam (PF17789) Pfam (PF07703) Pfam (PF01821) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) Pfam (PF07677) Pfam (PF01759) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) In PDB	Naja kaouthia (monocled cobra)	CVFk,Complement C3 homolog
4	A	5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid	non-polymer		444.5	1	Chemie (H1H)
5	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	370977.5
Non-Polymers*	Number of molecules	2
	Total formula weight	468.8
All*	Total formula weight	371446.3

*Water molecules are not included.