7YDX
Crystal structure of human RIPK1 kinase domain in complex with compound RI-962
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 294 | 33468.7 | 2 | UniProt (Q13546) Pfam (PF07714) In PDB | Homo sapiens (human) | Cell death protein RIP,Receptor-interacting protein 1,RIP-1 |
| 2 | A, B | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide | non-polymer | 480.6 | 2 | Chemie (3CI) | |||
| 3 | A, B | IODIDE ION | non-polymer | 126.9 | 7 | Chemie (IOD) | |||
| 4 | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Ala 34 | Cys 34 | engineered mutation |
| Ala 127 | Cys 127 | engineered mutation |
| Ala 233 | Cys 233 | engineered mutation |
| Ala 240 | Cys 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66937.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1849.4 | |
| All* | Total formula weight | 68786.9 |
