7Y8F
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with an Inhibitor 30o and GRIP Peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 260 | 29081.1 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | C, D | Grip peptide | polymer | 8 | 965.2 | 2 | UniProt (by SIFTS) (Q15788) In PDB | Homo sapiens | |
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
4 | B | [4-(trifluoromethyl)phenyl] (1~{S},2~{R},4~{S})-5-(4-hydroxyphenyl)-6-[4-(1,2,4-triazol-1-yl)phenyl]-7-oxabicyclo[2.2.1]heptane-2-sulfonate | non-polymer | 555.5 | 1 | Chemie (IC7) | |||
5 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A, B: 305 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Ala 295 | - | linker |
Gly 296 | - | linker |
Ala 297 | - | linker |
Gly 298 | - | linker |
Ala 299 | - | linker |
Gly 300 | - | linker |
Ala 301 | - | linker |
Gly 302 | - | linker |
Ala 303 | - | linker |
Gly 304 | - | linker |
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 60092.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 757.7 | |
All* | Total formula weight | 60850.3 |