7WVU
Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | fMet-Leu-Phe receptor | polymer | 371 | 40754.7 | 1 | UniProt (P21462) Pfam (PF00001) In PDB | Homo sapiens (human) | fMLP receptor,N-formyl peptide receptor,FPR,N-formylpeptide chemoattractant receptor |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40447.1 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | L | FME-LEU-PHE | polymer | 3 | 437.6 | 1 | Homo sapiens |
Sequence modifications
R: 2 - 321 (UniProt: P21462)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
Glu 322 | - | expression tag |
Phe 323 | - | expression tag |
Leu 324 | - | expression tag |
Glu 325 | - | expression tag |
Val 326 | - | expression tag |
Leu 327 | - | expression tag |
Phe 328 | - | expression tag |
Gln 329 | - | expression tag |
Gly 330 | - | expression tag |
Pro 331 | - | expression tag |
Gly 332 | - | expression tag |
Ser 333 | - | expression tag |
Trp 334 | - | expression tag |
Ser 335 | - | expression tag |
His 336 | - | expression tag |
Pro 337 | - | expression tag |
Gln 338 | - | expression tag |
Phe 339 | - | expression tag |
Glu 340 | - | expression tag |
Lys 341 | - | expression tag |
Gly 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Ala 345 | - | expression tag |
Gly 346 | - | expression tag |
Ala 347 | - | expression tag |
Ser 348 | - | expression tag |
Ala 349 | - | expression tag |
Gly 350 | - | expression tag |
Ser 351 | - | expression tag |
Trp 352 | - | expression tag |
Ser 353 | - | expression tag |
His 354 | - | expression tag |
Pro 355 | - | expression tag |
Gln 356 | - | expression tag |
Phe 357 | - | expression tag |
Glu 358 | - | expression tag |
Lys 359 | - | expression tag |
Gly 360 | - | expression tag |
Ser 361 | - | expression tag |
Asp 362 | - | expression tag |
Tyr 363 | - | expression tag |
Lys 364 | - | expression tag |
Asp 365 | - | expression tag |
Asp 366 | - | expression tag |
Asp 367 | - | expression tag |
Asp 368 | - | expression tag |
Lys 369 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 47 | Ser 47 | engineered mutation |
Thr 202 | Gly 202 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 128244.9 | |
All* | Total formula weight | 128244.9 |