7WN3
Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, E, G | von Willebrand antigen 2 | polymer | 741 | 81427.7 | 4 | UniProt (P04275) Pfam (PF00094) Pfam (PF08742) Pfam (PF01826) In PDB | Homo sapiens (human) | von Willebrand antigen II |
2 | F, H, C, D | von Willebrand factor | polymer | 490 | 54208.9 | 4 | UniProt (P04275) Pfam (PF16164) Pfam (PF00094) Pfam (PF08742) Pfam (PF01826) In PDB | Homo sapiens (human) | vWF |
3 | E, G, A, C, F... | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) | |||
4 | E, G, C, A, F... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 20 | Chemie (NAG) |
Sequence modifications
F, H, C, D: 764 - 1241 (UniProt: P04275)
PDB | External Database | Details |
---|---|---|
Met 1136 | Arg 1136 | engineered mutation |
Met 1143 | Glu 1143 | engineered mutation |
Gly 1242 | - | expression tag |
Leu 1243 | - | expression tag |
Val 1244 | - | expression tag |
Val 1245 | - | expression tag |
Pro 1246 | - | expression tag |
Pro 1247 | - | expression tag |
His 1248 | - | expression tag |
His 1249 | - | expression tag |
His 1250 | - | expression tag |
His 1251 | - | expression tag |
His 1252 | - | expression tag |
His 1253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 542546.4 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 5065.4 | |
All* | Total formula weight | 547611.8 |