7W22

Structure of the M. tuberculosis HtrA K436A mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Probable serine protease HtrA1	polymer	314	32464.3	1	UniProt (O06291) Pfam (PF13365) Pfam (PF13180) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	High-temperature requirement A protease
2		water	water		18.0	137	Chemie (HOH)

Sequence modifications

A: 224 - 528 (UniProt: O06291)

PDB	External Database	Details
Met 223	-	initiating methionine
Ala 436	Lys 436	engineered mutation
Leu 529	-	expression tag
Glu 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32464.3
All*	Total formula weight	32464.3

*Water molecules are not included.