7VAD

Cryo-EM structure of human NTCP complexed with YN69202Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sodium/bile acid cotransporter	polymer	343	38141.8	1	UniProt (Q14973) Pfam (PF01758) In PDB	Homo sapiens (Human)	Cell growth-inhibiting gene 29 protein,Na(+)/bile acid cotransporter,Na(+)/taurocholate transport protein,Sodium/taurocholate cotransporting polypeptide,Solute carrier family 10 member 1
2	H	Fab heavy chain from antibody IgG clone number YN69202	polymer	249	26574.7	1		Mus musculus
3	L	Fab light chain from antibody IgG clone number YN69202	polymer	219	24324.0	1		Mus musculus

Sequence modifications

A: 1 - 319 (UniProt: Q14973)

PDB	External Database	Details
Ala 261	Gln 261	engineered mutation
Ile 320	-	expression tag
Glu 321	-	expression tag
Asn 322	-	expression tag
Leu 323	-	expression tag
Tyr 324	-	expression tag
Phe 325	-	expression tag
Gln 326	-	expression tag
Gly 327	-	expression tag
Asp 328	-	expression tag
Tyr 329	-	expression tag
Lys 330	-	expression tag
Asp 331	-	expression tag
Asp 332	-	expression tag
Asp 333	-	expression tag
Asp 334	-	expression tag
Lys 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	89040.5
All*	Total formula weight	89040.5

*Water molecules are not included.