7V6B

Structure of the Dicer-2-R2D2 heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dicer-2, isoform A	polymer	1724	198134.7	1	UniProt (A1ZAW0) Pfam (PF00270) Pfam (PF00271) Pfam (PF03368) Pfam (PF20931) Pfam (PF02170) Pfam (PF00636) Pfam (PF00035) In PDB	Drosophila melanogaster (Fruit fly)	FI15132p1
2	B	R2D2	polymer	315	35517.7	1	UniProt (Q9VLW8) Pfam (PF00035) In PDB	Drosophila melanogaster (Fruit fly)	R2D2,R2d2,isoform A,isoform B,isoform C

Sequence modifications

A: 1 - 1722 (UniProt: A1ZAW0)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Leu 208	Met 208	engineered mutation

B: 1 - 311 (UniProt: Q9VLW8)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Phe -1	-	expression tag
Thr 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	233652.4
All*	Total formula weight	233652.4

*Water molecules are not included.