7UKR
Crystal Structure of SOS1 with MRTX0902, a Potent and Selective Inhibitor of the SOS1:KRAS Protein-Protein Interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Son of sevenless homolog 1 | polymer | 487 | 57103.3 | 2 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (human) | SOS-1 |
| 2 | A, B | 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl)pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile | non-polymer | 388.5 | 2 | Chemie (NKF) | |||
| 3 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 564 - 1049 (UniProt: Q07889)
| PDB | External Database | Details |
|---|---|---|
| Gly 563 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114206.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 776.9 | |
| All* | Total formula weight | 114983.5 |
