7T0A

Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	polymer	349	40913.2	1	UniProt (J9VSJ6) Pfam (PF01239) In PDB	Cryptococcus neoformans var. grubii H99	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha,variant
2	B	Protein farnesyltransferase subunit beta	polymer	520	56806.9	1	UniProt (T2BPA1) Pfam (PF00432) In PDB	Cryptococcus neoformans var. grubii H99	FTase-beta
3	A, B	1,2-ETHANEDIOL	non-polymer		62.1	59	Chemie (EDO)
4	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	B	(2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid	non-polymer		237.3	3	Chemie (3FX)
6	B	(5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one	non-polymer		565.4	1	Chemie (XMY)
7	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
8		water	water		18.0	421	Chemie (HOH)

Sequence modifications

A: 1 - 335 (UniProt: J9VSJ6)

PDB	External Database	Details
Met -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Leu 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	97720.1
Non-Polymers*	Number of molecules	65
	Total formula weight	5100.9
All*	Total formula weight	102821.0

*Water molecules are not included.