7T02
Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA repair protein Rad8 | polymer | 2348 | 263811.7 | 1 | UniProt (J9VI03) Pfam (PF00385) Pfam (PF00145) Pfam (PF00176) Pfam (PF00271) In PDB | Cryptococcus neoformans var. grubii H99 | |
| 2 | B | DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3') | polymer | 36 | 11168.2 | 1 | Cryptococcus neoformans | ||
| 3 | D | DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3') | polymer | 36 | 10999.1 | 1 | Cryptococcus neoformans | ||
| 4 | A | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
A: 58 - 2377 (UniProt: J9VI03)
| PDB | External Database | Details |
|---|---|---|
| Met 30 | - | expression tag |
| Ser 31 | - | expression tag |
| Tyr 32 | - | expression tag |
| Tyr 33 | - | expression tag |
| His 34 | - | expression tag |
| His 35 | - | expression tag |
| His 36 | - | expression tag |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| Asp 40 | - | expression tag |
| Tyr 41 | - | expression tag |
| Asp 42 | - | expression tag |
| Ile 43 | - | expression tag |
| Pro 44 | - | expression tag |
| Thr 45 | - | expression tag |
| Thr 46 | - | expression tag |
| Glu 47 | - | expression tag |
| Asn 48 | - | expression tag |
| Leu 49 | - | expression tag |
| Tyr 50 | - | expression tag |
| Phe 51 | - | expression tag |
| Gln 52 | - | expression tag |
| Gly 53 | - | expression tag |
| Ala 54 | - | expression tag |
| Met 55 | - | expression tag |
| Gly 56 | - | expression tag |
| Ser 57 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 285978.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 327.0 | |
| All* | Total formula weight | 286306.0 |
