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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7SYV

Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1218S rRNApolymer1870603100.91Oryctolagus cuniculus (rabbit)
2Z40S ribosomal protein S24polymer13115237.11UniProt (A0A5F9CNN4)
Pfam (PF01282)
UniProt (by SIFTS) (G1T3D8)
In PDB		Oryctolagus cuniculus (rabbit)
3AEukaryotic translation initiation factor 1A, X-chromosomalpolymer14416488.41UniProt (P47813)
Pfam (PF01176)
In PDB		Homo sapiens (human)eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C
4a40S ribosomal protein S25polymer12413645.01UniProt (G1TDB3)
Pfam (PF03297)
In PDB		Oryctolagus cuniculus (rabbit)
5B40S ribosomal protein SApolymer29532958.01UniProt (G1TLT8)
Pfam (PF00318)
Pfam (PF16122)
In PDB		Oryctolagus cuniculus (rabbit)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
6beS26polymer10111645.81UniProt (G1TFE8)
Pfam (PF01283)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S26
7CeS1polymer26430002.11UniProt (G1SS70)
Pfam (PF01015)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S3a
8ceS27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S27
9D40S ribosomal protein S2polymer22124441.81UniProt (G1TUT9)
In PDB		Oryctolagus cuniculus (rabbit)
10deS28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)
In PDB		Oryctolagus cuniculus (rabbit)Ribosomal protein S28
11EuS3polymer28131146.61UniProt (G1TNM3)
Pfam (PF07650)
Pfam (PF00189)
In PDB		Oryctolagus cuniculus (rabbit)Ribosomal protein S3
12eeS29polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)
In PDB		Oryctolagus cuniculus (rabbit)
13F40S ribosomal protein S4polymer26329654.91UniProt (G1TK17)
Pfam (PF00467)
Pfam (PF16121)
Pfam (PF08071)
Pfam (PF00900)
UniProt (by SIFTS) (G1TA47)
In PDB		Oryctolagus cuniculus (rabbit)
14feS30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S30
15GuS7polymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S5
16g40S ribosomal protein S27apolymer18821431.71UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)
In PDB		Oryctolagus cuniculus (rabbit)Ubiquitin carboxyl extension protein 80,Ubiquitin-40S ribosomal protein S27a
17HeS6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)
UniProt (by SIFTS) (A0A5K1UJS7)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S6
18hRACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)
In PDB		Oryctolagus cuniculus (rabbit)
19I40S ribosomal protein S7polymer43247356.21UniProt (G1SVB0)
In PDB		Oryctolagus cuniculus (rabbit)
20iMet-tRNA-i-Metpolymer7524231.51GenBank (174924)Oryctolagus cuniculus (rabbit)
21JeS8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S8
22n60s ribosomal protein l41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)
In PDB		Oryctolagus cuniculus (rabbit)
23KuS4polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Oryctolagus cuniculus (rabbit)Ribosomal protein S9
24xEukaryotic translation initiation factor 5Bpolymer62770788.01UniProt (G1TRL5)
Pfam (PF00009)
Pfam (PF11987)
Pfam (PF14578)
In PDB		Oryctolagus cuniculus (rabbit)Translation initiation factor IF-2
25LeS10polymer14917156.91UniProt (G1TPV3)
Pfam (PF03501)
In PDB		Oryctolagus cuniculus (rabbit)
26zHCV IRESpolymer400128746.11GenBank (149384897)hepatitis C virus genotype 1a
27MuS17polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S11
28NeS12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)
In PDB		Oryctolagus cuniculus (rabbit)40S ribosomal protein S12
29OuS15polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Oryctolagus cuniculus (rabbit)Ribosomal protein S13
30PuS11polymer16818134.01UniProt (G1U472)
Pfam (PF00411)
UniProt (by SIFTS) (G1T1F0)
In PDB		Oryctolagus cuniculus (rabbit)
31QuS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)
In PDB		Oryctolagus cuniculus (rabbit)
32RuS9polymer17219213.51UniProt (G1SGX4)
Pfam (PF00380)
In PDB		Oryctolagus cuniculus (rabbit)Ribosomal protein S16
33SeS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)
In PDB		Oryctolagus cuniculus (rabbit)
34TuS13polymer15217759.81UniProt (G1TPG3)
Pfam (PF00416)
In PDB		Oryctolagus cuniculus (rabbit)
35UeS19polymer14516235.81UniProt (G1TN62)
Pfam (PF01090)
In PDB		Oryctolagus cuniculus (rabbit)
36VuS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)
In PDB		Oryctolagus cuniculus (rabbit)
37W40S ribosomal protein S21polymer839124.41UniProt (G1TM82)
Pfam (PF01249)
In PDB		Oryctolagus cuniculus (rabbit)
38XuS8polymer13014865.61UniProt (G1TG89)
Pfam (PF00410)
In PDB		Oryctolagus cuniculus (rabbit)Ribosomal protein S15a
39YuS12polymer14315844.71UniProt (G1SZ47)
Pfam (PF00164)
In PDB		Oryctolagus cuniculus (rabbit)
40b, gZINC IONnon-polymer65.42Chemie (ZN)
41xGUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
42xMAGNESIUM IONnon-polymer24.31Chemie (MG)
43xSODIUM IONnon-polymer23.01Chemie (NA)
Sequence modifications
B: 1 - 295 (UniProt: G1TLT8)
PDBExternal DatabaseDetails
Thr 114Ala 114conflict
b: 2 - 102 (UniProt: G1TFE8)
PDBExternal DatabaseDetails
Arg 28Cys 28conflict
Ala 56Val 56conflict
D: 58 - 278 (UniProt: G1TUT9)
PDBExternal DatabaseDetails
Met 73Val 50conflict
Ser 101Ala 78conflict
Gly 119Ala 96conflict
Arg 194His 171conflict
Met 215Leu 192conflict
Arg 227Trp 204conflict
Gly 228Ser 205conflict
F: 1 - 263 (UniProt: G1TK17)
PDBExternal DatabaseDetails
Gly 25Ser 25conflict
Arg 51Lys 51conflict
Thr 78Ala 78conflict
Val 156Met 156conflict
J: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47conflict
W: 1 - 83 (UniProt: G1TM82)
PDBExternal DatabaseDetails
Asn 3Ser 3conflict
Asp 4Asn 4conflict
Gln 33Pro 33conflict
Phe 50Ser 50conflict
Ala 75Ser 75conflict
Asp 76His 76conflict
Lys 81Gln 81conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains39
Total formula weight1501160.4
Non-Polymers*Number of molecules5
Total formula weight701.3
All*Total formula weight1501861.7
*Water molecules are not included.

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PDB entries from 2024-05-15

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