7S7M
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Stromelysin-1 | polymer | 173 | 19416.5 | 1 | UniProt (P08254) Pfam (PF00413) In PDB | Homo sapiens (Human) | SL-1,Matrix metalloproteinase-3,MMP-3,Transin-1 |
| 2 | B | Metalloproteinase inhibitor 1 | polymer | 184 | 20592.5 | 1 | UniProt (P01033) Pfam (PF00965) In PDB | Homo sapiens (Human) | Erythroid-potentiating activity,EPA,Fibroblast collagenase inhibitor,Collagenase inhibitor,Tissue inhibitor of metalloproteinases 1,TIMP-1 |
| 3 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
B: 1 - 184 (UniProt: P01033)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | Leu 57 | engineered mutation |
| Asp 66 | Met 89 | engineered mutation |
| Gly 98 | Thr 121 | engineered mutation |
| Ser 131 | Pro 154 | engineered mutation |
| Asn 153 | Gln 176 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40009.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 251.1 | |
| All* | Total formula weight | 40260.1 |
