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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7QP6

Structure of the human 48S initiation complex in open state (h48S AUG open)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
11Eukaryotic translation initiation factor 3 subunit Bpolymer81392464.31UniProt (P55884)
Pfam (PF00076)
Pfam (PF08662)
In PDB		Homo sapiens (human)eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116
23Eukaryotic translation initiation factor 3 subunit Kpolymer21825083.61UniProt (Q9UBQ5)
Pfam (PF10075)
In PDB		Homo sapiens (human)eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28
34Eukaryotic translation initiation factor 3 subunit Fpolymer35737593.61UniProt (O00303)
Pfam (PF01398)
Pfam (PF13012)
In PDB		Homo sapiens (human)eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47
45Eukaryotic translation initiation factor 3 subunit Lpolymer56466803.71UniProt (Q9Y262)
Pfam (PF10255)
In PDB		Homo sapiens (human)eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein
56Eukaryotic translation initiation factor 3 subunit Mpolymer37442555.81UniProt (Q7L2H7)
Pfam (PF01399)
Pfam (PF18005)
In PDB		Homo sapiens (human)eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1
67mRNApolymer206539.21Homo sapiens (human)
78Eukaryotic translation initiation factor 3 subunit Hpolymer35239979.31UniProt (O15372)
Pfam (PF19445)
Pfam (PF01398)
In PDB		Homo sapiens (human)eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit
8960S ribosomal protein L41polymer253473.51UniProt (P62945)
Pfam (PF05162)
In PDB		Homo sapiens (human)HG12,Large ribosomal subunit protein eL41
9A18S rRNApolymer1869603102.31Homo sapiens (human)
10B40S ribosomal protein S11polymer15818468.81UniProt (P62280)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS17
11C40S ribosomal protein S4, X isoformpolymer26329654.91UniProt (P62701)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)
In PDB		Homo sapiens (human)SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4
12D40S ribosomal protein S9polymer19422641.61UniProt (P46781)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS4
13E40S ribosomal protein S23polymer14315844.71UniProt (P62266)
Pfam (PF00164)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS12
14F40S ribosomal protein S30polymer596668.91UniProt (P62861)
Pfam (PF04758)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS30
15G40S ribosomal protein S7polymer19422168.91UniProt (P62081)
Pfam (PF01251)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS7
16H40S ribosomal protein S27polymer849480.21UniProt (P42677)
Pfam (PF01667)
In PDB		Homo sapiens (human)Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27
17I40S ribosomal protein S13polymer15117259.41UniProt (P62277)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS15
18J40S ribosomal protein S15apolymer13014865.61UniProt (P62244)
Pfam (PF00410)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS8
19K40S ribosomal protein S21polymer839124.41UniProt (P63220)
Pfam (PF01249)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS21
20L40S ribosomal protein S2polymer29331376.51UniProt (P15880)
Pfam (PF00333)
Pfam (PF03719)
In PDB		Homo sapiens (human)40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5
21M40S ribosomal protein S17polymer13515578.21UniProt (P08708)
Pfam (PF00833)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS17
22N40S ribosomal protein SApolymer29532883.91UniProt (P08865)
Pfam (PF00318)
Pfam (PF16122)
In PDB		Homo sapiens (human)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2
23O40S ribosomal protein S3apolymer26430002.11UniProt (P61247)
Pfam (PF01015)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1
24P40S ribosomal protein S14polymer15116302.81UniProt (P62263)
Pfam (PF00411)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS11
25Q40S ribosomal protein S26polymer11513047.51UniProt (P62854)
Pfam (PF01283)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS26
26R40S ribosomal protein S8polymer20824263.41UniProt (P62241)
Pfam (PF01201)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS8
27S40S ribosomal protein S6polymer24928751.91UniProt (P62753)
Pfam (PF01092)
In PDB		Homo sapiens (human)Phosphoprotein NP33,Small ribosomal subunit protein eS6
28T40S ribosomal protein S24polymer13315463.31UniProt (P62847)
Pfam (PF01282)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS24
29V40S ribosomal protein S5polymer20422913.51UniProt (P46782)
Pfam (PF00177)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS7
30Y40S ribosomal protein S16polymer14616477.41UniProt (P62249)
Pfam (PF00380)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS9
31Z40S ribosomal protein S3polymer24326729.41UniProt (P23396)
Pfam (PF07650)
Pfam (PF00189)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS3
32a40S ribosomal protein S10polymer16518933.81UniProt (P46783)
Pfam (PF03501)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS10
33b40S ribosomal protein S15polymer14517076.21UniProt (P62841)
Pfam (PF00203)
In PDB		Homo sapiens (human)RIG protein,Small ribosomal subunit protein uS19
34cReceptor of activated protein C kinase 1polymer31735115.71UniProt (P63244)
Pfam (PF00400)
In PDB		Homo sapiens (human)Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
35d40S ribosomal protein S19polymer14516091.61UniProt (P39019)
Pfam (PF01090)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS19
36e40S ribosomal protein S25polymer12513776.21UniProt (P62851)
Pfam (PF03297)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS25
37f40S ribosomal protein S18polymer15217759.81UniProt (P62269)
Pfam (PF00416)
In PDB		Homo sapiens (human)Ke-3,Ke3,Small ribosomal subunit protein uS13
38h40S ribosomal protein S20polymer11913398.81UniProt (P60866)
Pfam (PF00338)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS10
39i40S ribosomal protein S29polymer566690.81UniProt (P62273)
Pfam (PF00253)
In PDB		Homo sapiens (human)Small ribosomal subunit protein uS14
40kUbiquitin-40S ribosomal protein S27apolymer15618004.01UniProt (P62979)
Pfam (PF00240)
Pfam (PF01599)
In PDB		Homo sapiens (human)Ubiquitin carboxyl extension protein 80
41m40S ribosomal protein S12polymer13214539.01UniProt (P25398)
Pfam (PF01248)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS12
42n40S ribosomal protein S28polymer697855.11UniProt (P62857)
Pfam (PF01200)
In PDB		Homo sapiens (human)Small ribosomal subunit protein eS28
43oEukaryotic translation initiation factor 3 subunit Gpolymer32035662.01UniProt (O75821)
Pfam (PF12353)
Pfam (PF00076)
In PDB		Homo sapiens (human)eIF3g,Eukaryotic translation initiation factor 3 RNA-binding subunit,eIF-3 RNA-binding subunit,Eukaryotic translation initiation factor 3 subunit 4,eIF-3-delta,eIF3 p42,eIF3 p44
44pEukaryotic translation initiation factor 1polymer11312752.51UniProt (P41567)
Pfam (PF01253)
In PDB		Homo sapiens (human)eIF1,A121,Protein translation factor SUI1 homolog,Sui1iso1
45qEukaryotic translation initiation factor 1A, X-chromosomalpolymer14416488.41UniProt (P47813)
Pfam (PF01176)
In PDB		Homo sapiens (human)eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C
46rEukaryotic translation initiation factor 2 subunit 1polymer31536161.21UniProt (P05198)
Pfam (PF00575)
Pfam (PF07541)
In PDB		Homo sapiens (human)Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha
47sEukaryotic translation initiation factor 2 subunit 2polymer33338454.51UniProt (P20042)
Pfam (PF01873)
In PDB		Homo sapiens (human)Eukaryotic translation initiation factor 2 subunit beta,eIF-2-beta
48tEukaryotic translation initiation factor 2 subunit 3polymer47251178.41UniProt (P41091)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF09173)
In PDB		Homo sapiens (human)Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX
49uEukaryotic translation initiation factor 3 subunit Apolymer1382166903.81UniProt (Q14152)
Pfam (PF01399)
In PDB		Homo sapiens (human)eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185
50vEukaryotic translation initiation factor 3 subunit Epolymer44552281.61UniProt (P60228)
Pfam (PF09440)
Pfam (PF01399)
Pfam (PF21357)
In PDB		Homo sapiens (human)eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48
51wInitiator Met-tRNA-ipolymer7524231.51GenBank (174924)Homo sapiens (human)
52xEukaryotic translation initiation factor 3 subunit Dpolymer54864060.81UniProt (O15371)
Pfam (PF05091)
In PDB		Homo sapiens (human)eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta,eIF3 p66
53yEukaryotic translation initiation factor 3 subunit Cpolymer913105503.91UniProt (Q99613)
Pfam (PF05470)
Pfam (PF01399)
In PDB		Homo sapiens (human)eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110
54Q, kZINC IONnon-polymer65.42Chemie (ZN)
55d, fMAGNESIUM IONnon-polymer24.32Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains53
Total formula weight2140482.0
Non-Polymers*Number of molecules4
Total formula weight179.4
All*Total formula weight2140661.4
*Water molecules are not included.

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PDB entries from 2024-05-15

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