7P5E
Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Kelch-like ECH-associated protein 1 | polymer | 321 | 35251.4 | 1 | UniProt (Q9Z2X8) Pfam (PF01344) In PDB | Mus musculus (Mouse) | Cytosolic inhibitor of Nrf2,INrf2 |
2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | A | 1-[6-[3-(dimethylcarbamoyl)phenyl]pyridin-2-yl]-5-(trifluoromethyl)pyrazole-4-carboxylic acid | non-polymer | 404.3 | 1 | Chemie (5VX) | |||
5 | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
A: 322 - 624 (UniProt: Q9Z2X8)
PDB | External Database | Details |
---|---|---|
Met 304 | - | initiating methionine |
Gly 305 | - | expression tag |
Ser 306 | - | expression tag |
Ser 307 | - | expression tag |
His 308 | - | expression tag |
His 309 | - | expression tag |
His 310 | - | expression tag |
His 311 | - | expression tag |
His 312 | - | expression tag |
His 313 | - | expression tag |
Ser 314 | - | expression tag |
Ser 315 | - | expression tag |
Gly 316 | - | expression tag |
Leu 317 | - | expression tag |
Val 318 | - | expression tag |
Pro 319 | - | expression tag |
Arg 320 | - | expression tag |
Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35251.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 517.9 | |
All* | Total formula weight | 35769.3 |