7NWK
Crystal structure of CDK9-Cyclin T1 bound by compound 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 9 | polymer | 330 | 38031.1 | 1 | UniProt (P50750) Pfam (PF00069) In PDB | Homo sapiens (Human) | C-2K,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Serine/threonine-protein kinase PITALRE,Tat-associated kinase complex catalytic subunit |
| 2 | B | Cyclin-T1 | polymer | 258 | 29965.3 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB | Homo sapiens (Human) | CycT1,Cyclin-T |
| 3 | A | N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide | non-polymer | 368.4 | 1 | Chemie (UT5) |
Sequence modifications
B: 2 - 259 (UniProt: O60563)
| PDB | External Database | Details |
|---|---|---|
| Arg 77 | Gln 77 | conflict |
| Gly 96 | Glu 96 | conflict |
| Leu 241 | Phe 241 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67996.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 68364.8 |
