7NMI
Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cellular tumor antigen p53 | polymer | 40 | 4667.2 | 1 | UniProt (P04637) Pfam (PF08563) Pfam (PF18521) In PDB | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
2 | B | S100P-ANXA2 chimera | polymer | 512 | 57376.2 | 1 | UniProt (P25815) UniProt (P07355) Pfam (PF01023) Pfam (PF00191) In PDB | Homo sapiens (Human) | Migration-inducing gene 9 protein,MIG9,Protein S100-E,S100 calcium-binding protein P,Protein S100-P,Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36,Annexin A2 |
3 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | B | CALCIUM ION | non-polymer | 40.1 | 9 | Chemie (CA) | |||
5 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
B: 1 - 95 (UniProt: P25815)
B: 104 - 198 (UniProt: P25815)
B: 201 - 511 (UniProt: P07355)
PDB | External Database | Details |
---|---|---|
His 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 96 | - | linker |
Gly 97 | - | linker |
Gly 98 | - | linker |
Gly 99 | - | linker |
Ser 100 | - | linker |
Gly 101 | - | linker |
Gly 102 | - | linker |
Ser 103 | - | linker |
Thr 199 | - | linker |
Ser 200 | - | linker |
PDB | External Database | Details |
---|---|---|
Glu 238 | Ala 66 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 62043.4 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 452.8 | |
All* | Total formula weight | 62496.2 |