7MEM
CryoEM structure of monoclonal Fab 045-09 2B05 binding the lateral patch of influenza virus H1 HA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E, C, F | Hemagglutinin HA1 chain | polymer | 331 | 36729.4 | 3 | UniProt (C3W5S1) Pfam (PF00509) In PDB | Influenza A virus (strain swl A/California/04/2009 H1N1) | |
2 | L, J, K | Light chain of monoclonal antibody 045-09 2B05 | polymer | 107 | 11769.1 | 3 | Homo sapiens | ||
3 | H, G, I | Heavy chain of monoclonal antibody 045-09 2B05 | polymer | 120 | 12805.2 | 3 | Homo sapiens | ||
4 | D, A, B | Hemagglutinin HA2 chain | polymer | 174 | 19905.0 | 3 | UniProt (C3W5S1) Pfam (PF00509) In PDB | Influenza A virus (strain swl A/California/04/2009 H1N1) | |
5 | M, O, Q | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 3 | In PDB GlyTouCan (G86851RC) | |||
6 | N, P, R | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
7 | E, C, F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
E, C, F: 11 - 329 (UniProt: C3W5S1)
D, A, B: 1 - 174 (UniProt: C3W5S1)
PDB | External Database | Details |
---|---|---|
Ala 7 | - | expression tag |
Asp 8 | - | expression tag |
Pro 9 | - | expression tag |
Gly 10 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 47 | Glu 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 243626.3 | |
Branched | Number of molecules | 6 |
Total formula weight | 2375.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 247328.8 |