7LXT

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O	20S proteasome alpha-1 subunit	polymer	260	29531.7	2	UniProt (Q8IAR3) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
2	B, P	20S proteasome alpha-2 subunit	polymer	235	26556.4	2	UniProt (C6KST3) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
3	C, Q	20S proteasome alpha-3 subunit	polymer	246	27977.7	2	UniProt (Q8IDG3) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
4	D, R	20S proteasome alpha-4 subunit	polymer	241	27263.3	2	UniProt (Q8IDG2) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
5	E, S	20S proteasome alpha-5 subunit	polymer	256	28417.4	2	UniProt (Q8IBI3) Pfam (PF00227) Pfam (PF10584) In PDB	Plasmodium falciparum (isolate 3D7)
6	F, T	20S proteasome alpha-6 subunit	polymer	254	28871.7	2	UniProt (Q8IK90) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum
7	G, U	20S proteasome alpha-7 subunit	polymer	252	29324.3	2	UniProt (O77396) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
8	H, V	20S proteasome beta-1 subunit	polymer	252	29143.9	2	UniProt (Q8I0U7) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
9	I, W	20S proteasome beta-2 subunit	polymer	229	25104.9	2	UniProt (Q8I6T3) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
10	J, X	20S proteasome beta-3 subunit	polymer	218	24533.1	2	UniProt (Q8I261) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
11	K, Y	20S proteasome beta-4 subunit	polymer	195	22889.1	2	UniProt (Q8IKC9) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
12	L, Z	20S proteasome beta-5 subunit	polymer	211	23620.6	2	UniProt (Q8IJT1) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
13	M, a	20S proteasome beta-6 subunit	polymer	240	27301.2	2	UniProt (A0A5K1K7U1) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
14	N, b	20S proteasome beta-7 subunit	polymer	265	30909.9	2	UniProt (Q7K6A9) Pfam (PF00227) In PDB	Plasmodium falciparum (isolate 3D7)
15	H, I, L, V, W...	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE	non-polymer		384.2	6	Chemie (BO2)

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	762890.3
Non-Polymers*	Number of molecules	6
	Total formula weight	2305.4
All*	Total formula weight	765195.7

*Water molecules are not included.