7LGS
Structure of EGFR_D770_N771insNPG/V948R in complex with covalent inhibitor Osimertinib.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Epidermal growth factor receptor | polymer | 331 | 37687.5 | 4 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A, B, C, D | ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | non-polymer | 501.6 | 4 | Chemie (Q6K) | |||
| 3 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | B | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 5 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 696 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 695 | - | expression tag |
| Gly 773 | - | insertion |
| Asn 774 | - | insertion |
| Pro 775 | - | insertion |
| Arg 951 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150750.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2571.0 | |
| All* | Total formula weight | 153321.1 |
