7L8K

Crystal structure of human GPX4-U46C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phospholipid hydroperoxide glutathione peroxidase	polymer	192	21888.1	1	UniProt (P36969) Pfam (PF00255) In PDB	Homo sapiens (Human)	PHGPx,Glutathione peroxidase 4,GSHPx-4
2	A	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5		water	water		18.0	190	Chemie (HOH)

Sequence modifications

A: 3 - 170 (UniProt: P36969)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
Leu 0	-	expression tag
Glu 1	-	expression tag
Ala 2	-	expression tag
Cys 46	Sec 73	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21888.1
Non-Polymers*	Number of molecules	5
	Total formula weight	436.2
All*	Total formula weight	22324.3

*Water molecules are not included.