Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7KZP

Structure of the human Fanconi anaemia Core complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, S	Fanconi anemia group A protein	polymer	1477	165513.0	2	UniProt (O15360) Pfam (PF15865) Pfam (PF03511) In PDB	Homo sapiens (Human)	Protein FACA
2	B, O	Fanconi anemia group B protein	polymer	884	100640.2	2	UniProt (Q8NB91) In PDB	Homo sapiens (Human)	Protein FACB,Fanconi anemia-associated polypeptide of 95 kDa,FAAP95
3	C	Fanconi anemia group C protein	polymer	583	66290.4	1	UniProt (Q00597) Pfam (PF02106) In PDB	Homo sapiens (Human)	Protein FACC
4	E	Fanconi anemia group E protein	polymer	555	61026.1	1	UniProt (Q9HB96) Pfam (PF11510) In PDB	Homo sapiens (Human)	Protein FACE
5	F	Fanconi anemia group F protein	polymer	399	45108.3	1	UniProt (Q9NPI8) Pfam (PF11107) In PDB	Homo sapiens (Human)	Protein FACF
6	G, H	Fanconi anemia group G protein	polymer	641	70873.7	2	UniProt (O15287) In PDB	Homo sapiens (Human)	Protein FACG,DNA repair protein XRCC9
7	L, M	E3 ubiquitin-protein ligase FANCL	polymer	394	45204.0	2	UniProt (Q9NW38) Pfam (PF09765) Pfam (PF18890) Pfam (PF18891) Pfam (PF11793) In PDB	Homo sapiens (Human)	Fanconi anemia group L protein,Fanconi anemia-associated polypeptide of 43 kDa,FAAP43,RING-type E3 ubiquitin transferase FANCL
8	P, Q	Fanconi anemia core complex-associated protein 100	polymer	906	96513.9	2	UniProt (Q0VG06) Pfam (PF15146) In PDB	Homo sapiens (Human)	Fanconi anemia-associated protein of 100 kDa
9	W	Fanconi anemia core complex-associated protein 20	polymer	39	4041.7	1		Homo sapiens (Human)
10	G, L	ZINC ION	non-polymer		65.4	3	Chemie (ZN)

Sequence modifications

A, S: 1 - 1455 (UniProt: O15360)

PDB	External Database	Details
Ala 1456	-	expression tag
Ala 1457	-	expression tag
Ala 1458	-	expression tag
Lys 1459	-	expression tag
Leu 1460	-	expression tag
Val 1461	-	expression tag
Asp 1462	-	expression tag
Glu 1463	-	expression tag
Asp 1464	-	expression tag
Leu 1465	-	expression tag
Tyr 1466	-	expression tag
Phe 1467	-	expression tag
Gln 1468	-	expression tag
Ser 1469	-	expression tag
Asp 1470	-	expression tag
Tyr 1471	-	expression tag
Lys 1472	-	expression tag
Asp 1473	-	expression tag
Asp 1474	-	expression tag
Asp 1475	-	expression tag
Asp 1476	-	expression tag
Lys 1477	-	expression tag

B, O: 1 - 859 (UniProt: Q8NB91)

PDB	External Database	Details
Met -24	-	initiating methionine
Asp -23	-	expression tag
Tyr -22	-	expression tag
Lys -21	-	expression tag
Asp -20	-	expression tag
Asp -19	-	expression tag
Asp -18	-	expression tag
Asp -17	-	expression tag
Lys -16	-	expression tag
Glu -15	-	expression tag
Asn -14	-	expression tag
Leu -13	-	expression tag
Tyr -12	-	expression tag
Phe -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Arg -6	-	expression tag
Lys -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Thr -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

C: 1 - 558 (UniProt: Q00597)

PDB	External Database	Details
Met -24	-	initiating methionine
Asp -23	-	expression tag
Tyr -22	-	expression tag
Lys -21	-	expression tag
Asp -20	-	expression tag
Asp -19	-	expression tag
Asp -18	-	expression tag
Asp -17	-	expression tag
Lys -16	-	expression tag
Glu -15	-	expression tag
Asn -14	-	expression tag
Leu -13	-	expression tag
Tyr -12	-	expression tag
Phe -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Arg -6	-	expression tag
Lys -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Thr -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

E: 1 - 536 (UniProt: Q9HB96)

PDB	External Database	Details
Met -18	-	initiating methionine
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

F: 1 - 374 (UniProt: Q9NPI8)

PDB	External Database	Details
Met -24	-	initiating methionine
Asp -23	-	expression tag
Tyr -22	-	expression tag
Lys -21	-	expression tag
Asp -20	-	expression tag
Asp -19	-	expression tag
Asp -18	-	expression tag
Asp -17	-	expression tag
Lys -16	-	expression tag
Glu -15	-	expression tag
Asn -14	-	expression tag
Leu -13	-	expression tag
Tyr -12	-	expression tag
Phe -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Arg -6	-	expression tag
Lys -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Thr -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

G, H: 1 - 622 (UniProt: O15287)

PDB	External Database	Details
Met -18	-	initiating methionine
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

L, M: 1 - 375 (UniProt: Q9NW38)

PDB	External Database	Details
Met -18	-	initiating methionine
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

P, Q: 1 - 881 (UniProt: Q0VG06)

PDB	External Database	Details
Met -24	-	initiating methionine
Asp -23	-	expression tag
Tyr -22	-	expression tag
Lys -21	-	expression tag
Asp -20	-	expression tag
His -19	-	expression tag
Asp -18	-	expression tag
Gly -17	-	expression tag
Asp -16	-	expression tag
Tyr -15	-	expression tag
Lys -14	-	expression tag
Asp -13	-	expression tag
His -12	-	expression tag
Asp -11	-	expression tag
Ile -10	-	expression tag
Asp -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Lys -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	14
Polymers	Total formula weight	1133955.9
Non-Polymers*	Number of molecules	3
Non-Polymers*	Total formula weight	196.2
All*	Total formula weight	1134152.2

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
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