7KZB

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Fab heavy chain of CR3014-C8 antibody	polymer	231	24812.7	1		Homo sapiens
2	L	Fab light chain of CR3014-C8 antibody	polymer	214	23577.0	1		Homo sapiens
3	C	Spike glycoprotein	polymer	204	22975.7	1	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein
4	A	Fab heavy chain of CR3022-B6 antibody	polymer	230	24428.4	1		Homo sapiens
5	B	Fab light chain of CR3022-B6 antibody	polymer	214	23346.9	1		Homo sapiens
6	D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
7	L	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8		water	water		18.0	5	Chemie (HOH)

Sequence modifications

C: 333 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 529	-	expression tag
Ser 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	119140.7
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	119746.7

*Water molecules are not included.