7K2F

Kelch domain of human KEAP1 bound to Nrf2 cyclic peptide, c[GAEETGE]

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	X, A	Kelch-like ECH-associated protein 1	polymer	336	37015.2	2	UniProt (Q14145) Pfam (PF01344) In PDB	Homo sapiens (Human)	Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19
2	C	Nrf2 cyclic peptide,c[GAEETGE]	polymer	7	691.6	1		synthetic construct

Sequence modifications

X, A: 312 - 623 (UniProt: Q14145)

PDB	External Database	Details
Met 289	-	initiating methionine
Gly 290	-	expression tag
Ser 291	-	expression tag
Ser 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
Ser 299	-	expression tag
Ser 300	-	expression tag
Gly 301	-	expression tag
Gly 302	-	expression tag
Glu 303	-	expression tag
Asn 304	-	expression tag
Leu 305	-	expression tag
Tyr 306	-	expression tag
Phe 307	-	expression tag
Gln 308	-	expression tag
Gly 309	-	expression tag
His 310	-	expression tag
Met 311	-	expression tag
Ser 319	Cys 319	conflict
Ser 613	Cys 613	conflict
Ser 622	Cys 622	conflict
Ser 624	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	74722.1
All*	Total formula weight	74722.1

*Water molecules are not included.