7FJJ

human Pol III pre-termination complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA-directed RNA polymerase III subunit RPC1	polymer	1390	155860.1	1	UniProt (O14802) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C1,DNA-directed RNA polymerase III largest subunit,DNA-directed RNA polymerase III subunit A,RNA polymerase III 155 kDa subunit,RPC155,RNA polymerase III subunit C160
2	B	DNA-directed RNA polymerase III subunit RPC2	polymer	1133	127953.9	1	UniProt (Q9NW08) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C2,C128,DNA-directed RNA polymerase III 127.6 kDa polypeptide,DNA-directed RNA polymerase III subunit B
3	C	DNA-directed RNA polymerases I and III subunit RPAC1	polymer	346	39301.7	1	UniProt (O15160) Pfam (PF01193) Pfam (PF01000) In PDB	Homo sapiens (Human)	RNA polymerases I and III subunit AC1,AC40,DNA-directed RNA polymerases I and III 40 kDa polypeptide,RPA40,RPA39,RPC40
4	D	DNA-directed RNA polymerase III subunit RPC9	polymer	148	16894.0	1	UniProt (O75575) Pfam (PF03874) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C9,Calcitonin gene-related peptide-receptor component protein,HsC17
5	E	DNA-directed RNA polymerases I, II, and III subunit RPABC1	polymer	210	24584.2	1	UniProt (P19388) Pfam (PF03871) Pfam (PF01191) In PDB	Homo sapiens (Human)	RNA polymerases I,II,and III subunit ABC1,DNA-directed RNA polymerase II 23 kDa polypeptide,DNA-directed RNA polymerase II subunit E,RPB5 homolog,XAP4
6	F	DNA-directed RNA polymerases I, II, and III subunit RPABC2	polymer	127	14491.0	1	UniProt (P61218) Pfam (PF01192) In PDB	Homo sapiens (Human)	RNA polymerases I,II,and III subunit ABC2,DNA-directed RNA polymerase II subunit F,DNA-directed RNA polymerases I,and III 14.4 kDa polypeptide,RPABC14.4,RPB14.4,RPB6 homolog,RPC15
7	G	DNA-directed RNA polymerase III subunit RPC8	polymer	204	22938.8	1	UniProt (Q9Y535) Pfam (PF03876) Pfam (PF08292) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C8,DNA-directed RNA polymerase III subunit H,RNA polymerase III subunit 22.9 kDa subunit,RPC22.9
8	H	DNA-directed RNA polymerases I, II, and III subunit RPABC3	polymer	150	17162.3	1	UniProt (P52434) Pfam (PF03870) In PDB	Homo sapiens (Human)	RNA polymerases I,II,and III subunit ABC3,DNA-directed RNA polymerase II subunit H,DNA-directed RNA polymerases I,and III 17.1 kDa polypeptide,RPB17,RPB8 homolog,hRPB8
9	I	DNA-directed RNA polymerase III subunit RPC10	polymer	108	12338.1	1	UniProt (Q9Y2Y1) Pfam (PF02150) Pfam (PF01096) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C10,DNA-directed RNA polymerase III subunit K,RNA polymerase III 12.5 kDa subunit,RPC12.5,RNA polymerase III subunit C11,HsC11p,RPC11,hRPC11
10	J	DNA-directed RNA polymerases I, II, and III subunit RPABC5	polymer	67	7655.1	1	UniProt (P62875) Pfam (PF01194) In PDB	Homo sapiens (Human)	RNA polymerases I,II,and III subunit ABC5,DNA-directed RNA polymerase III subunit L,RNA polymerase II 7.6 kDa subunit,RPB7.6,RPB10 homolog
11	K	DNA-directed RNA polymerases I and III subunit RPAC2	polymer	133	15259.2	1	UniProt (P0DPB6) Pfam (PF13656) Pfam (PF01193) In PDB	Homo sapiens (Human)	RNA polymerases I and III subunit AC2,AC19,DNA-directed RNA polymerase I subunit D,RNA polymerase I 16 kDa subunit,RPA16,RPC16,hRPA19
12	L	DNA-directed RNA polymerases I, II, and III subunit RPABC4	polymer	58	7018.2	1	UniProt (P53803) Pfam (PF03604) In PDB	Homo sapiens (Human)	RNA polymerases I,II,and III subunit ABC4,ABC10-alpha,DNA-directed RNA polymerase II subunit K,RNA polymerase II 7.0 kDa subunit,RPB7.0,RPB10alpha
13	M	DNA-directed RNA polymerase III subunit RPC5	polymer	708	80004.0	1	UniProt (Q9NVU0) Pfam (PF04801) Pfam (PF19725) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C5,DNA-directed RNA polymerase III 80 kDa polypeptide
14	N	DNA-directed RNA polymerase III subunit RPC4	polymer	398	44471.9	1	UniProt (P05423) Pfam (PF05132) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C4,DNA-directed RNA polymerase III subunit D,Protein BN51,RNA polymerase III 47 kDa subunit,RPC53 homolog
15	O	DNA-directed RNA polymerase III subunit RPC3	polymer	534	60692.6	1	UniProt (Q9BUI4) Pfam (PF08221) Pfam (PF05645) Pfam (PF20912) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C3,DNA-directed RNA polymerase III subunit C,RNA polymerase III 62 kDa subunit,RPC62
16	P	DNA-directed RNA polymerase III subunit RPC6	polymer	316	35726.9	1	UniProt (Q9H1D9) Pfam (PF05158) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C6,DNA-directed RNA polymerase III subunit F,RNA polymerase III 39 kDa subunit,RPC39
17	Q	DNA-directed RNA polymerase III subunit RPC7	polymer	223	25953.5	1	UniProt (O15318) Pfam (PF11705) In PDB	Homo sapiens (Human)	RNA polymerase III subunit C7,DNA-directed RNA polymerase III subunit G,RNA polymerase III 32 kDa apha subunit,RPC32-alpha,RNA polymerase III 32 kDa subunit,RPC32
18	R	RNA (5'-R(*CP*CP*GP*GP*GP*UP*GP*CP*UP*G)-3')	polymer	10	3208.9	1		Homo sapiens
19	X	non-template DNA	polymer	54	16602.6	1		Homo sapiens
20	Y	template DNA	polymer	54	16570.6	1		Homo sapiens
21	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
22	J, L, A, B, I	ZINC ION	non-polymer		65.4	7	Chemie (ZN)
23	P	IRON/SULFUR CLUSTER	non-polymer		351.6	1	Chemie (SF4)

Sequence modifications

I: 1 - 108 (UniProt: Q9Y2Y1)

PDB	External Database	Details
Ala 24	Ser 24	variant

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	744687.8
Non-Polymers*	Number of molecules	9
	Total formula weight	833.8
All*	Total formula weight	745521.6

*Water molecules are not included.