7FIH
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Engineered Guanine nucleotide-binding protein G(s) subunit alpha | polymer | 361 | 41879.5 | 1 | Bos taurus (Bovine) | ||
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38613.2 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Rat) | Transducin beta chain 1 |
| 3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (Bovine) | G gamma-I |
| 4 | R | Lutropin-choriogonadotropic hormone receptor | polymer | 697 | 78655.9 | 1 | UniProt (P22888) Pfam (PF13306) Pfam (PF00001) In PDB | Homo sapiens (Human) | LH/CG-R,Luteinizing hormone receptor,LHR,LSH-R |
| 5 | X | Glycoprotein hormones alpha chain | polymer | 115 | 12960.0 | 1 | UniProt (P01215) Pfam (PF00236) In PDB | Homo sapiens (Human) | Anterior pituitary glycoprotein hormones common subunit alpha,Choriogonadotropin alpha chain,Chorionic gonadotrophin subunit alpha,CG-alpha,Follicle-stimulating hormone alpha chain,FSH-alpha,Follitropin alpha chain,Luteinizing hormone alpha chain,LSH-alpha,Lutropin alpha chain,Thyroid-stimulating hormone alpha chain,TSH-alpha,Thyrotropin alpha chain |
| 6 | Y | Choriogonadotropin subunit beta 3 | polymer | 165 | 17755.7 | 1 | UniProt (P0DN86) Pfam (PF00007) In PDB | Homo sapiens (Human) | Choriogonadotropin subunit beta,CG-beta,Chorionic gonadotropin chain beta |
| 7 | R | 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide | non-polymer | 514.7 | 1 | Chemie (55Z) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
R: 28 - 699 (UniProt: P22888)
| PDB | External Database | Details |
|---|---|---|
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 11 | - | expression tag |
| Tyr 12 | - | expression tag |
| Lys 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Val 18 | - | expression tag |
| Glu 19 | - | expression tag |
| Asn 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Tyr 22 | - | expression tag |
| Phe 23 | - | expression tag |
| Gln 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Ile 277 | Ser 277 | engineered mutation |
| His 700 | - | expression tag |
| His 701 | - | expression tag |
| His 702 | - | expression tag |
| His 703 | - | expression tag |
| His 704 | - | expression tag |
| His 705 | - | expression tag |
| His 706 | - | expression tag |
| His 707 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 197725.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 514.7 | |
| All* | Total formula weight | 198240.0 |
