7EPM

human LDHC complexed with NAD+ and ethylamino acetic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	L-lactate dehydrogenase C chain	polymer	341	37528.4	2	UniProt (P07864) Pfam (PF00056) Pfam (PF02866) In PDB	Homo sapiens (Human)	LDH-C,Cancer/testis antigen 32,CT32,LDH testis subunit,LDH-X
2	A, B	2-(ethylamino)-2-oxidanylidene-ethanoic acid	non-polymer		117.1	2	Chemie (J9X)
3	A, B	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
4	A, B	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
5		water	water		18.0	27	Chemie (HOH)

Sequence modifications

A, B: 3 - 333 (UniProt: P07864)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 2	-	expression tag
Glu 56	Leu 55	engineered mutation
Gln 332	Ile 331	engineered mutation
Leu 334	-	expression tag
Glu 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75056.8
Non-Polymers*	Number of molecules	13
	Total formula weight	2425.6
All*	Total formula weight	77482.4

*Water molecules are not included.