7DSQ

Overall structure of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	4F2 cell-surface antigen heavy chain	polymer	647	70160.8	1	UniProt (J3KPF3) Pfam (PF16028) Pfam (PF00128) UniProt (by SIFTS) (P08195) In PDB	Homo sapiens (Human)	4F2hc, Solute carrier family 3 (Activators of dibasic and neutral amino acid transport),member 2,isoform CRA_a
2	B	Large neutral amino acids transporter small subunit 1	polymer	527	57186.9	1	UniProt (Q01650) Pfam (PF13520) In PDB	Homo sapiens (Human)	4F2 light chain,4F2LC,CD98 light chain,Integral membrane protein E16,E16,L-type amino acid transporter 1,hLAT1,Solute carrier family 7 member 5,y+ system cationic amino acid transporter
3	C, D, E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
4	B	3,5-DIIODOTYROSINE	non-polymer		433.0	1	Chemie (TYI)
5	B	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	2	Chemie (Y01)
6	B	1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE	non-polymer		705.0	1	Chemie (3PH)
7		water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 2 - 631 (UniProt: J3KPF3)

PDB	External Database	Details
Met -13	-	initiating methionine
Ala -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Arg 1	-	expression tag
Leu 632	-	expression tag
Glu 633	-	expression tag

B: 2 - 507 (UniProt: Q01650)

PDB	External Database	Details
Met -19	-	initiating methionine
Ala -18	-	expression tag
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Pro -7	-	expression tag
Asp -6	-	expression tag
Glu -5	-	expression tag
Val -4	-	expression tag
Asp -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Arg 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	127347.7
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	4
	Total formula weight	2111.4
All*	Total formula weight	131156.8

*Water molecules are not included.