7DFP
Human dopamine D2 receptor in complex with spiperone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | D(2) dopamine receptor,Soluble cytochrome b562 | polymer | 360 | 40590.7 | 1 | UniProt (P14416) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | Dopamine D2 receptor,Cytochrome b-562,Cytochrome b-562,Dopamine D2 receptor |
2 | B | FabL | polymer | 215 | 23884.3 | 1 | Mus musculus | ||
3 | C | FabH | polymer | 220 | 23443.1 | 1 | Mus musculus | ||
4 | A | 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | non-polymer | 395.5 | 1 | Chemie (SIP) |
Sequence modifications
A: 35 - 220 (UniProt: P14416)
A: 1001 - 1040 (UniProt: P0ABE7)
A: 1066 - 1106 (UniProt: P0ABE7)
A: 364 - 443 (UniProt: P14416)
PDB | External Database | Details |
---|---|---|
Met 34 | - | initiating methionine |
Lys 121 | Ser 121 | engineered mutation |
Trp 123 | Leu 123 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1041 | - | linker |
Ser 1042 | - | linker |
Gly 1063 | - | linker |
Ser 1064 | - | linker |
Gly 1065 | - | linker |
Ile 1098 | Arg 120 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Gly 1106 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 444 | - | expression tag |
Glu 445 | - | expression tag |
Asn 446 | - | expression tag |
Leu 447 | - | expression tag |
Tyr 448 | - | expression tag |
Phe 449 | - | expression tag |
Gln 450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 87918.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 395.5 | |
All* | Total formula weight | 88313.6 |