7CAB

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein	polymer	1208	133945.5	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein,SARS-CoV-2 Spike glycoprotein
2	D, E, F, G, H...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
3	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	30	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 682	Arg 682	engineered mutation
Ser 683	Arg 683	engineered mutation
Ser 685	Arg 685	engineered mutation
Met 835	Lys 835	engineered mutation
Met 844	Ile 844	engineered mutation
Tyr 846	Ala 846	engineered mutation
Ala 848	Asp 848	engineered mutation
Met 849	Leu 849	engineered mutation
Gln 850	Ile 850	engineered mutation
Met 851	Cys 851	engineered mutation
Tyr 853	Gln 853	engineered mutation
Arg 854	Lys 854	engineered mutation
Pro 986	Lys 986	engineered mutation
Pro 987	Val 987	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	401836.5
Branched	Number of molecules	15
	Total formula weight	6366.0
Non-Polymers*	Number of molecules	30
	Total formula weight	6636.2
All*	Total formula weight	414838.8

*Water molecules are not included.