7CA5

Cryo-EM structure of human GABA(B) receptor in apo state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Gamma-aminobutyric acid type B receptor subunit 1	polymer	771	87248.2	1	UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003) In PDB	Homo sapiens (Human)	Gb1
2	B	Gamma-aminobutyric acid type B receptor subunit 2	polymer	822	92231.3	1	UniProt (O75899) Pfam (PF01094) Pfam (PF00003) In PDB	Homo sapiens (Human)	Gb2,G-protein coupled receptor 51,HG20

Sequence modifications

A: 165 - 900 (UniProt: Q9UBS5)

PDB	External Database	Details
Met 139	-	initiating methionine
Arg 140	-	expression tag
Leu 141	-	expression tag
Leu 142	-	expression tag
Thr 143	-	expression tag
Ala 144	-	expression tag
Leu 145	-	expression tag
Phe 146	-	expression tag
Ala 147	-	expression tag
Tyr 148	-	expression tag
Phe 149	-	expression tag
Ile 150	-	expression tag
Val 151	-	expression tag
Ala 152	-	expression tag
Leu 153	-	expression tag
Ile 154	-	expression tag
Leu 155	-	expression tag
Ala 156	-	expression tag
Phe 157	-	expression tag
Ser 158	-	expression tag
Val 159	-	expression tag
Ser 160	-	expression tag
Ala 161	-	expression tag
Lys 162	-	expression tag
Ser 163	-	expression tag
Met 164	-	expression tag
Ser 901	-	expression tag
Gly 902	-	expression tag
Arg 903	-	expression tag
Leu 904	-	expression tag
Glu 905	-	expression tag
Val 906	-	expression tag
Leu 907	-	expression tag
Phe 908	-	expression tag
Gln 909	-	expression tag

B: 1 - 787 (UniProt: O75899)

PDB	External Database	Details
Ser 788	-	expression tag
Gly 789	-	expression tag
Arg 790	-	expression tag
Gly 791	-	expression tag
Gly 792	-	expression tag
Ser 793	-	expression tag
Glu 794	-	expression tag
Asn 795	-	expression tag
Leu 796	-	expression tag
Tyr 797	-	expression tag
Phe 798	-	expression tag
Gln 799	-	expression tag
Gly 800	-	expression tag
Gly 801	-	expression tag
Ser 802	-	expression tag
Gly 803	-	expression tag
Ser 804	-	expression tag
Gly 805	-	expression tag
Gly 806	-	expression tag
Asp 807	-	expression tag
Tyr 808	-	expression tag
Lys 809	-	expression tag
Asp 810	-	expression tag
Asp 811	-	expression tag
Asp 812	-	expression tag
Asp 813	-	expression tag
Lys 814	-	expression tag
Asp 815	-	expression tag
Tyr 816	-	expression tag
Lys 817	-	expression tag
Asp 818	-	expression tag
Asp 819	-	expression tag
Asp 820	-	expression tag
Asp 821	-	expression tag
Lys 822	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	179479.5
All*	Total formula weight	179479.5

*Water molecules are not included.