7C9N
Crystal structure of SETDB1 tudor domain in complexed with Compound 1.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Histone-lysine N-methyltransferase SETDB1 | polymer | 240 | 27613.6 | 2 | UniProt (Q15047) Pfam (PF18300) Pfam (PF18359) Pfam (PF18358) In PDB | Homo sapiens (Human) | ERG-associated protein with SET domain,ESET,Histone H3-K9 methyltransferase 4,H3-K9-HMTase 4,Lysine N-methyltransferase 1E,SET domain bifurcated 1 |
2 | B, A | 3,5-dimethyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]pyrrolo[3,2-d]pyrimidin-4-one | non-polymer | 351.4 | 2 | Chemie (FN9) | |||
3 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
B, A: 190 - 410 (UniProt: Q15047)
PDB | External Database | Details |
---|---|---|
Gly 171 | - | expression tag |
Ser 172 | - | expression tag |
Ser 173 | - | expression tag |
His 174 | - | expression tag |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
His 179 | - | expression tag |
Ser 180 | - | expression tag |
Ser 181 | - | expression tag |
Gly 182 | - | expression tag |
Glu 183 | - | expression tag |
Asn 184 | - | expression tag |
Leu 185 | - | expression tag |
Tyr 186 | - | expression tag |
Phe 187 | - | expression tag |
Gln 188 | - | expression tag |
Gly 189 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 55227.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 702.9 | |
All* | Total formula weight | 55930.0 |