7BTV
Crystal structure of EHMT2 SET domain in complex with compound 5.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histone-lysine N-methyltransferase EHMT2 | polymer | 283 | 32604.9 | 2 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) In PDB | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | A, B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | A, B | N~2~-{4-methoxy-3-[3-(pyrrolidin-1-yl)propoxy]phenyl}-N~4~,6-dimethylpyrimidine-2,4-diamine | non-polymer | 371.5 | 2 | Chemie (N47) | |||
| 5 | water | water | 18.0 | 322 | Chemie (HOH) |
Sequence modifications
A, B: 913 - 1193 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 911 | - | expression tag |
| Ser 912 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65209.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2063.1 | |
| All* | Total formula weight | 67272.9 |
