7AKF

Structure of DYRK2 in complex with compound 50

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity tyrosine-phosphorylation-regulated kinase 2	polymer	429	49600.9	1	UniProt (Q92630) Pfam (PF00069) In PDB	Homo sapiens (Human)
2	A	4-(2,3-dimethyl-1-benzofuran-5-yl)pyridine-2,6-diamine	non-polymer		253.3	1	Chemie (RK5)
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4		water	water		18.0	88	Chemie (HOH)

Sequence modifications

A: 146 - 552 (UniProt: Q92630)

PDB	External Database	Details
Met 124	-	initiating methionine
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
Ser 131	-	expression tag
Ser 132	-	expression tag
Gly 133	-	expression tag
Val 134	-	expression tag
Asp 135	-	expression tag
Leu 136	-	expression tag
Gly 137	-	expression tag
Thr 138	-	expression tag
Glu 139	-	expression tag
Asn 140	-	expression tag
Leu 141	-	expression tag
Tyr 142	-	expression tag
Phe 143	-	expression tag
Gln 144	-	expression tag
Ser 145	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49600.9
Non-Polymers*	Number of molecules	2
	Total formula weight	288.8
All*	Total formula weight	49889.7

*Water molecules are not included.