6ZY7

Cryo-EM structure of the entire Human topoisomerase II alpha in State 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	DNA topoisomerase 2-alpha	polymer	1531	174654.4	2	UniProt (P11388) Pfam (PF02518) Pfam (PF00204) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) Pfam (PF08070) In PDB	Homo sapiens (Human)	DNA topoisomerase II,alpha isozyme
2	D, F	DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3')	polymer	17	5099.3	2		Homo sapiens
3	E, C	DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3')	polymer	13	4080.7	2		Homo sapiens
4	B, A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
5	D, F	(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside	non-polymer		588.6	2	Chemie (EVP)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	367668.8
Non-Polymers*	Number of molecules	4
	Total formula weight	2189.5
All*	Total formula weight	369858.3

*Water molecules are not included.