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6ZY5

Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1B, ADNA topoisomerase 2-alphapolymer1531174654.42UniProt (P11388)
Pfam (PF02518)
Pfam (PF00204)
Pfam (PF01751)
Pfam (PF16898)
Pfam (PF00521)
Pfam (PF08070)
In PDB
Homo sapiens (Human)DNA topoisomerase II,alpha isozyme
2D, FDNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3')polymer175099.32Homo sapiens
3E, CDNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3')polymer134080.72Homo sapiens
4D, F(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranosidenon-polymer588.62Chemie (EVP)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight367668.8
Non-Polymers*Number of molecules2
Total formula weight1177.1
All*Total formula weight368845.9
*Water molecules are not included.

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PDB entries from 2024-05-15

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