6ZR9
The crystal structure of the complex of hCAVII with 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 7 | polymer | 274 | 30925.7 | 1 | UniProt (P43166) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase VII,Carbonic anhydrase VII,CA-VII |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | 2-[4-(diphenylmethyl)piperazin-1-yl]-~{N}-(4-sulfamoylphenyl)ethanamide | non-polymer | 464.6 | 1 | Chemie (QOZ) | |||
4 | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: -1 - 262 (UniProt: P43166)
PDB | External Database | Details |
---|---|---|
Met -3 | - | initiating methionine |
Gly -2 | - | expression tag |
Ser 183 | Cys 185 | engineered mutation |
Ser 217 | Cys 219 | engineered mutation |
Leu 263 | - | expression tag |
Glu 264 | - | expression tag |
His 265 | - | expression tag |
His 266 | - | expression tag |
His 267 | - | expression tag |
His 268 | - | expression tag |
His 269 | - | expression tag |
His 270 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 30925.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 530.0 | |
All* | Total formula weight | 31455.7 |