6ZOD

Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8 groove, and TM1/TM2 groove of the fully induced AcrB T protomer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Multidrug efflux pump subunit AcrB	polymer	1057	114736.3	3	UniProt (P31224) Pfam (PF00873) In PDB	Escherichia coli (strain K12)	AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B
2	D, E	DARPIN	polymer	169	18317.6	2		synthetic construct
3	A, C	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	7	Chemie (LMT)
4	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	15	Chemie (EDO)
5	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	A, B	DECANE	non-polymer		142.3	2	Chemie (D10)
7	B, A	FUSIDIC ACID	non-polymer		516.7	4	Chemie (FUA)
8	B	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
9	B	Octadecane	non-polymer		254.5	1	Chemie (8K6)
10	B, C	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
11	C	PHOSPHATIDYLETHANOLAMINE	non-polymer		734.0	2	Chemie (PTY)
12	C	DODECANE	non-polymer		170.3	1	Chemie (D12)
13	C	HEXANE	non-polymer		86.2	1	Chemie (HEX)
14		water	water		18.0	149	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 1049 (UniProt: P31224)

PDB	External Database	Details
Leu 1050	-	expression tag
Glu 1051	-	expression tag
His 1052	-	expression tag
His 1053	-	expression tag
His 1054	-	expression tag
His 1055	-	expression tag
His 1056	-	expression tag
His 1057	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	380844.0
Non-Polymers*	Number of molecules	41
	Total formula weight	9650.5
All*	Total formula weight	390494.5

*Water molecules are not included.