6YKG
Structure-based exploration of selectivity for ATM inhibitors in Huntingtons disease
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | AAA | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 636 | 72592.8 | 1 | UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34 |
2 | AAA | 4-morpholin-4-yl-6-[(2~{R})-2-(phenylmethyl)pyrrolidin-1-yl]-1~{H}-pyridin-2-one | non-polymer | 339.4 | 1 | Chemie (OZ8) | |||
3 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
AAA: 268 - 880 (UniProt: Q8NEB9)
PDB | External Database | Details |
---|---|---|
Met 245 | - | initiating methionine |
His 246 | - | expression tag |
His 247 | - | expression tag |
His 248 | - | expression tag |
His 249 | - | expression tag |
His 250 | - | expression tag |
His 251 | - | expression tag |
Ser 252 | - | expression tag |
Ser 253 | - | expression tag |
Gly 254 | - | expression tag |
Val 255 | - | expression tag |
Asp 256 | - | expression tag |
Leu 257 | - | expression tag |
Gly 258 | - | expression tag |
Thr 259 | - | expression tag |
Glu 260 | - | expression tag |
Asn 261 | - | expression tag |
Leu 262 | - | expression tag |
Tyr 263 | - | expression tag |
Phe 264 | - | expression tag |
Gln 265 | - | expression tag |
Ser 266 | - | expression tag |
Met 267 | - | expression tag |
Ala 612 | Phe 612 | conflict |
Asn 616 | Leu 616 | conflict |
Leu 634 | Ile 634 | conflict |
Leu 682 | Met 682 | conflict |
Trp 684 | Phe 684 | conflict |
Gly 687 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 72592.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 339.4 | |
All* | Total formula weight | 72932.2 |