6Y4P

Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Calmodulin-1	polymer	149	16851.6	1	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
2	B	Ryanodine receptor 2	polymer	30	3478.2	1	UniProt (E9Q401) UniProt (by SIFTS) (Q92736) In PDB	Mus musculus (Mouse)	RyR2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor
3	A	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
4		water	water		18.0	61	Chemie (HOH)

Sequence modifications

A: 0 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Ile 53	Asn 54	engineered mutation

B: 3614 - 3640 (UniProt: E9Q401)

PDB	External Database	Details
Ser 3611	-	expression tag
Asn 3612	-	expression tag
Ala 3613	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20329.8
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	20490.1

*Water molecules are not included.