6XVJ
Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Vascular endothelial growth factor receptor 2 | polymer | 322 | 36989.6 | 1 | UniProt (P35968) Pfam (PF07714) In PDB | Homo sapiens (Human) | VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1 |
2 | A | ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | non-polymer | 486.6 | 1 | Chemie (O35) | |||
3 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 806 - 1171 (UniProt: P35968)
PDB | External Database | Details |
---|---|---|
- | Thr 940 | deletion |
- | Lys 941 | deletion |
- | Gly 942 | deletion |
- | Ala 943 | deletion |
- | Arg 944 | deletion |
- | Phe 945 | deletion |
- | Arg 946 | deletion |
- | Gln 947 | deletion |
- | Gly 948 | deletion |
- | Lys 949 | deletion |
- | Asp 950 | deletion |
- | Tyr 951 | deletion |
- | Val 952 | deletion |
- | Gly 953 | deletion |
- | Ala 954 | deletion |
- | Ile 955 | deletion |
- | Pro 956 | deletion |
- | Val 957 | deletion |
- | Asp 958 | deletion |
- | Leu 959 | deletion |
- | Lys 960 | deletion |
- | Arg 961 | deletion |
- | Arg 962 | deletion |
- | Leu 963 | deletion |
- | Asp 964 | deletion |
- | Ser 965 | deletion |
- | Ile 966 | deletion |
- | Thr 967 | deletion |
- | Ser 968 | deletion |
- | Ser 969 | deletion |
- | Gln 970 | deletion |
- | Ser 971 | deletion |
- | Ser 972 | deletion |
- | Ala 973 | deletion |
- | Ser 974 | deletion |
- | Ser 975 | deletion |
- | Gly 976 | deletion |
- | Phe 977 | deletion |
- | Val 978 | deletion |
- | Glu 979 | deletion |
- | Glu 980 | deletion |
- | Lys 981 | deletion |
- | Ser 982 | deletion |
- | Leu 983 | deletion |
- | Ser 984 | deletion |
- | Asp 985 | deletion |
- | Val 986 | deletion |
- | Glu 987 | deletion |
- | Glu 988 | deletion |
- | Glu 989 | deletion |
Val 990 | Glu 990 | engineered mutation |
Glu 1172 | - | expression tag |
Asn 1173 | - | expression tag |
Leu 1174 | - | expression tag |
Tyr 1175 | - | expression tag |
Phe 1176 | - | expression tag |
Gln 1177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36989.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 486.6 | |
All* | Total formula weight | 37476.2 |