6X3O

Co-structure of BTK kinase domain with L-005191930 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase BTK	polymer	271	31598.3	2	UniProt (Q06187) Pfam (PF07714) In PDB	Homo sapiens (Human)	Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase
2	A, B	4-{8-amino-3-[(6R,8aS)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide	non-polymer		565.5	2	Chemie (ULY)
3	A, B	4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide	non-polymer		518.6	2	Chemie (5WE)
4		water	water		18.0	344	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63196.6
Non-Polymers*	Number of molecules	4
	Total formula weight	2168.4
All*	Total formula weight	65364.9

*Water molecules are not included.