6W9I

SUBSTITUTED BENZYLOXYTRICYCLIC COMPOUNDS AS RETINOIC ACID-RELATED ORPHAN RECEPTOR GAMMA T AGONISTS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Nuclear receptor ROR-gamma, Steroid receptor coactivator 1 fusion	polymer	285	32886.9	1	UniProt (P51449) UniProt (Q15788) Pfam (PF00104) In PDB	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma, SRC-1
2	A	1-(benzyloxy)-4-{1-[(4-fluorophenyl)sulfonyl]cyclopentyl}benzene	non-polymer		410.5	1	Chemie (Z7D)
3		water	water		18.0	222	Chemie (HOH)

Sequence modifications

A: 265 - 508 (UniProt: P51449)

PDB	External Database	Details
Met 244	-	initiating methionine
Gly 245	-	expression tag
Ser 246	-	expression tag
Ser 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Ser 254	-	expression tag
Ser 255	-	expression tag
Gly 256	-	expression tag
Leu 257	-	expression tag
Val 258	-	expression tag
Pro 259	-	expression tag
Arg 260	-	expression tag
Gly 261	-	expression tag
Ser 262	-	expression tag
His 263	-	expression tag
Met 264	-	expression tag
Ser 509	-	linker
Gly 510	-	linker
Gly 511	-	linker
Ser 512	-	linker
Gly 513	-	linker
Gly 514	-	linker

A: 515 - 528 (UniProt: Q15788)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32886.9
Non-Polymers*	Number of molecules	1
	Total formula weight	410.5
All*	Total formula weight	33297.4

*Water molecules are not included.