6W5S
NPC1 structure in GDN micelles at pH 8.0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NPC intracellular cholesterol transporter 1 | polymer | 1311 | 146083.7 | 1 | UniProt (O15118) Pfam (PF16414) Pfam (PF12349) Pfam (PF02460) In PDB | Homo sapiens (Human) | Niemann-Pick C1 protein |
| 2 | B, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C | alpha-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G66019PC) | |||
| 4 | D | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 6 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 7 | A | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 1 | Chemie (POV) |
Sequence modifications
A: 1 - 1278 (UniProt: O15118)
| PDB | External Database | Details |
|---|---|---|
| Leu 1279 | - | expression tag |
| Glu 1280 | - | expression tag |
| Gly 1281 | - | expression tag |
| Ser 1282 | - | expression tag |
| Asp 1283 | - | expression tag |
| Glu 1284 | - | expression tag |
| Val 1285 | - | expression tag |
| Asp 1286 | - | expression tag |
| Ala 1287 | - | expression tag |
| Gly 1288 | - | expression tag |
| Ser 1289 | - | expression tag |
| His 1290 | - | expression tag |
| His 1291 | - | expression tag |
| His 1292 | - | expression tag |
| His 1293 | - | expression tag |
| His 1294 | - | expression tag |
| His 1295 | - | expression tag |
| His 1296 | - | expression tag |
| His 1297 | - | expression tag |
| His 1298 | - | expression tag |
| His 1299 | - | expression tag |
| Gly 1300 | - | expression tag |
| Ser 1301 | - | expression tag |
| Val 1302 | - | expression tag |
| Glu 1303 | - | expression tag |
| Asp 1304 | - | expression tag |
| Tyr 1305 | - | expression tag |
| Lys 1306 | - | expression tag |
| Asp 1307 | - | expression tag |
| Asp 1308 | - | expression tag |
| Asp 1309 | - | expression tag |
| Asp 1310 | - | expression tag |
| Lys 1311 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 146083.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2021.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3137.6 | |
| All* | Total formula weight | 151243.2 |
